Divergent ontogeny of Tissue Resident Memory and Tissue Resident Exhausted CD8⁺ T cells underlies distinct functional potential.

ABSTRACT: Persistent antigen stimulation promotes differentiation of exhausted CD8⁺ T (T_EX) cells. T_EX cells are distinct from circulating memory T (T_CIRCM) cells but share many features with tissue-resident memory (T_RM) cells established following infection resolution. CD8⁺ T cells co-expressing residency- and exhaustion-associated molecules in chronic diseases often correlate with clinical outcomes. However, the relationship between these cells and conventional T_RM or T_EX cells remains unclear. Here, we show that chronic antigen stimulation drives development of tissue-resident T_EX (TR-T_EX) cells that are ontologically and functionally distinct from T_RM cells generated after ant

SUBMITTER: Park SL 

PROVIDER: S-EPMC12363886 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature