Increased atherosclerosis and expression of inflammarafts in macrophage foam cells in AIBP-deficient mice.

ABSTRACT:

Background

Atherosclerotic lesions comprise different populations of macrophages, including lipid-laden macrophage foam cells and non-foamy, inflammatory macrophages, playing different roles in disease progression. Previous studies demonstrated higher expression of inflammarafts - enlarged, cholesterol-rich lipid rafts hosting assemblies of inflammatory receptors - in non-foamy, inflammatory macrophages, as opposed to lower inflammarafts in lipid-lade macrophage foam cells. Apolipoprotein A-I Binding Protein (AIBP) facilitates cholesterol efflux from macrophages and has been shown to reduce inflammatory responses and protect against atherosclerosis. This study investigated the effect of AIBP deficiency on inflammaraft expression in aortic foam cells and non-foamy macrophages in hyp

SUBMITTER: Li S 

PROVIDER: S-EPMC12363900 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature