Tau drives cell specific functional isolation of the hippocampal formation.

ABSTRACT: A major challenge in understanding Alzheimer's disease is linking changes that occur across different biological scales. For example, how do changes in individual neurons build into widespread network disruptions? To address this, we used flexible mesh electronics to record neuronal activity for six months in ThyTau22 mice, a model of tauopathy that accumulates mutant human tau with age. Electrophysiology was recorded simultaneously from the hippocampus and entorhinal cortex of awake, behaving mice. At all ages we observed neuron-level, tau-driven silencing including ages without detectable tangles or cell-death. We found an unexpected phenomenon: neurons silenced by tau spontaneously recover individual firing patterns, yet these neurons fail to regain normal network interactions. Thus, as

SUBMITTER: Zwang TJ 

PROVIDER: S-EPMC12363901 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature