Convergent evolution through independent rearrangements in the primate amylase locus.

ABSTRACT: Structurally complex regions of the genome are increasingly recognized as engines of evolutionary convergence due to their propensity to generate recurrent gene duplications that give rise to similar gene expression patterns and traits across lineages. However the mutational mechanisms driving these duplications and the regulatory changes enabling novel expression patterns remain poorly understood. The primate amylase locus, marked by independent gene duplications, provides an ideal model to investigate these dynamics. Leveraging high-quality genome assemblies from 53 primates and multi-tissue transcriptomes from Old World monkeys, we reconstructed the evolutionary history of the recurrent gene duplications across the primate phylogeny. Our data suggest that lineage-specific LTR retrotrans

SUBMITTER: Karageorgiou C 

PROVIDER: S-EPMC12363942 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature