Progression of Dark-Adapted Visual Fields Over 3 Years in the Rate of Progression in USH2A-Related Retinal Degeneration (RUSH2A) Study.

ABSTRACT:

Purpose

To document the time course of visual sensitivity loss in dark-adapted visual fields (DAVF). To explore longitudinal relationships between DAVF measured using two-color dark-adapted chromatic and rod function from electroretinogram (ERG) and full-field stimulus testing in the RUSH2A study.

Methods

Full-field rod mean sensitivity, number of rod loci, maximum sensitivity, DAVF V30 were measured in one eye for DAVF ancillary study participants at the RUSH2A 12-month, 24-month, 36-month and 48-month visits. Loci where cyan relative to red sensitivity was greater than 5 dB on dark-adapted chromatic perimetry were considered rod mediated. Correlation coefficients (r) between changes in DAVF measures with changes in standard clinical measures were estimated.

Results

SUBMITTER: Birch DG 

PROVIDER: S-EPMC12364011 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature