Continuous Biochemical Profiling of the Gastrointestinal Tract Using an Integrated Smart Capsule.

ABSTRACT: The gastrointestinal tract contains a wealth of chemical information that can be used to decipher the health of the digestive and nervous systems. Traditional methods of analysis, such as fecal analysis and biopsies, are invasive, costly, and incapable of providing real-time metabolic and hormone profiling across the gastrointestinal tract. Commercial ingestible capsule sensors have been developed, but only monitor basic markers, such as pH and pressure, neglecting detailed chemical analysis. Here we report an integrated smart capsule that can simultaneously detect a spectrum of biochemical markers, including electrolytes, metabolites, and hormones. The capsule, which is termed PillTrek, is 7 mm in diameter and 25 mm in length, and houses a miniaturized wireless electrochemical workstation

SUBMITTER: Min J 

PROVIDER: S-EPMC12364029 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature