Dietary Soy Preserves Cognitive Function in Experimental Fetal Alcohol Spectrum Disorder: Role of Increased Signaling through Notch and Gonadotropin Releasing Hormone Networks.

ABSTRACT:

Background

Neurodevelopmental abnormalities in experimental fetal alcohol spectrum disorder (FASD) are associated with impaired signaling through complex pathways that mediate neuronal survival, growth, migration, energy metabolism, and plasticity. Gestational dietary soy prevents alcohol-related impairments in placentation and FASD-associated fetal anomalies.

Objective

This study was designed to determine if gestational dietary soy would be sufficient to normalize cognitive function in young adolescent offspring after chronic in utero exposure to alcohol. In addition, efforts were made to characterize the mechanisms of FASD prevention by maternal dietary soy.

Methods

Pregnant Long Evans rats were fed isocaloric liquid diets containing 0% or 26% caloric ethanol with c

SUBMITTER: de la Monte SM 

PROVIDER: S-EPMC12364082 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature