Scorpion (Hottentotta tamulus) venom pre-exposure delays functional recovery in mice following peripheral nerve injury.

ABSTRACT: Scorpion sting leads to profound challenges of central nervous system (CNS) impairments such as neuro-inflammation, unconsciousness, aberrant ion channels physiology, epilepsy and may become fatal due to heart failure. However persistence of Hottentotta tamulus venom in peripheral nerves and subsequent influence on regenerative process of injured peripheral nerve remains unknown. Current study reports the persistence of H. tamulus venom components 30-days following its intraperitoneal administration in sciatic nerves (SN) of mice pre-exposed through either a single-toxin exposure (STE) or multiple-toxin exposure (MTE). Of note, venom pre-exposure delays and compromises the sensori-motor functional recovery in STE and MTE mice following standard sciatic nerve crush injury. Histological inve

SUBMITTER: Khan A 

PROVIDER: S-EPMC12364329 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature