Epidemiological factors associated with immunological resistance in household contacts exposed to active tuberculosis in South Africa: A logistic regression analysis.

ABSTRACT:

Introduction

Studying individuals who do not get infected with tuberculosis (TB) despite being persistently exposed to infectious TB may enable us to identify TB protective mechanisms.

Methods

Between Apr 2015 and Apr 2017, we recruited adult household contacts (HHCs) of index TB cases (GeneXpert and sputum smear-positive) in Rustenburg, South Africa. HIV-uninfected HHCs who tested positive on both Tuberculin Skin Test (TST) and QuantiFERON-TB Gold In-tube (QFT) were defined as having latent TB infection (QFT + TST+), and those who tested double negative (QFT-TST-) were defined as uninfected with TB. The level of risk for TB infection was evaluated using an epidemiologic risk score. We compared epidemiological and clinical characteristics between the groups and used logic re

SUBMITTER: Maenetje N 

PROVIDER: S-EPMC12364365 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature