Prominent Alveolar Bone Graft Substitute Derived from Silk Fibroin/Hyaluronic Acid/Demineralized Dentin Matrix Hybrid Hydrogel.

ABSTRACT: Bone graft substitutes are commonly used to repair large bone defect, and restoring the alveolar bone defects in height and width is a major challenge in restorative dentistry. In comparison with clinic bone graft substitutes such as bovine-derived powder and hydroxyapatite, demineralized dentin matrix (DDM) is a valuable alternative due to its compositional similarity to human-derived bone. However, a challenge remains in using DDM for bone rehabilitation, particularly in maintaining spatial morphology due to its granular form. This study developed an effective bone graft substitute using DDM particles in a fast-cured silk fibroin/hyaluronic acid methacrylate (SF/HAMA) hydrogel, which adheres well to the alveolar bone defect and rapidly gels under blue light. In vitro and in vivo experime

SUBMITTER: Chen R 

PROVIDER: S-EPMC12364377 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature