Rankings of tuberculosis antibiotic treatment regimens are sensitive to spatial scale, detection limit, and initial host bacterial burden.

ABSTRACT: Pulmonary infection after inhalation of Mycobacterium tuberculosis (Mtb) causes tuberculosis (TB). TB presents with lung granulomas - complex spheroidal structures composed of immune cells and bacteria. Granulomas often have centralized caseum (necrotic tissue) where mycobacteria are quarantined, complicating and prolonging multi-antibiotic regimens. Determining which antibiotic regimens are optimal for reducing treatment time and toxicity is a goal of recent TB eradication campaigns. Clinical trials are expensive and challenging, making it difficult to untangle which host-pathogen interactions drive heterogeneous infection and treatment outcomes observed both within and between hosts. To determine responses to antibiotic regimens, we simulate treatments in HostSim, our whole-host mechanis

SUBMITTER: Michael CT 

PROVIDER: S-EPMC12364387 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature