Applications of the partial-order continual reassessment method in the early development of treatment combinations.

ABSTRACT: Combination therapy is increasingly being explored as a promising approach for improving cancer treatment outcomes. However, identifying effective dose combinations in early oncology drug development is challenging due to limited sample sizes in early-phase clinical trials. This task becomes even more complex when multiple agents are being escalated simultaneously, potentially leading to a loss of monotonic toxicity order with respect to the dose. Traditional single-agent trial designs are insufficient for this multi-dimensional problem, necessitating the development and implementation of dose-finding methods specifically designed for drug combinations. While, in practice, approaches to this problem have focused on preselecting combinations with a known toxicity order and applying single-a

SUBMITTER: Wages NA 

PROVIDER: S-EPMC12364408 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature