Magnesium phosphate functionalized graphene oxide and PLGA composite matrices with enhanced mechanical and osteogenic properties for bone regeneration.

ABSTRACT: Bone defects affect millions of people annually, making bone tissue of particular interest for developing treatments. Current strategies for healing suffer drawbacks. Regenerative engineering seeks to achieve efficient bone regeneration by utilizing synthetic bone grafts to evade these drawbacks. One material that offers such benefits is a class of functional graphenic material, known as Phosphate Graphenes. While many of our studies have focused on Calcium Phosphate Graphene, magnesium is also osteogenic. Therefore, in this study, we utilized regenerative engineering techniques to incorporate Magnesium Phosphate Graphene (MgPG) into poly(lactic-co-glycolic acid) (PLGA) to fabricate composite microsphere-based matrices as a potential synthetic bone graft. Employing different amounts of MgP

SUBMITTER: Whitfield T 

PROVIDER: S-EPMC12364435 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature