Gliogenesis from the subventricular zone modulates the extracellular matrix at the glial scar after brain ischemia.

ABSTRACT: Activation of the subventricular zone (SVZ) following cerebral ischemia is one of the brain's early responses to counteract neuron loss and minimize tissue damage. Impaired brain regions communicate with the SVZ through various chemotactic signals that promote cell migration and differentiation, primarily involving neural stem cells, neuroblasts, or glioblasts. However, the activation of gliogenesis and the role of newly formed astrocytes in the post-ischemic scenario remain subjects of debate. We have previously demonstrated that adenosine release after brain ischemia prompts the SVZ to generate new astrocytes. Here, we used transient brain ischemia in mice to identify the cellular origin of these astrocytes within the SVZ neurogenic niche and investigate their role in the pathological pr

SUBMITTER: Ardaya M 

PROVIDER: S-EPMC12364484 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature