Molecular Docking and Functional Analyses Reveal the Chondroprotective and Anti-Inflammatory Potential of Statins in Osteoarthritis.

ABSTRACT: Osteoarthritis is a progressive degenerative joint disorder characterised by cartilage degradation and chronic inflammation. Beyond their well-established lipid-lowering properties, statins, particularly pitavastatin and rosuvastatin, have demonstrated promising anti-inflammatory and chondroprotective effects. This study comprehensively evaluated these effects on human primary chondrocytes using an integrative approach involving in silico and in vitro experiments. Key molecular targets, including NF-κB, IL-1β and SOX9, were analysed to elucidate the mechanisms underlying the therapeutic potential of these statins. Molecular docking analyses using the CB-Dock2 platform revealed strong binding affinities of both statins with the target proteins, with pitavastatin exhibiting a higher binding

SUBMITTER: Kilinc BR 

PROVIDER: S-EPMC12364615 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature