Development and Application of a 1,8-Naphthalimide-Based Fluorescent Probe for Sensitive Detection of Hydrogen Sulfide in Human Blood Serum.

ABSTRACT: This work implies the preparation, structural and fluorescent characterization, and application of the 1,8-naphthalimide-based fluorescent probe for H₂S detection in human blood serum. The mechanism of fluorescent detection of H₂S is based on the reduction of the azide group, as the chemical reactive site, in the fluorescent probe structure, to the amino group. Compound 2 possesses another important structural motif, ethanolamine moiety, which modulates physicochemical properties. The synthetic pathway for the preparation of compound 2 is consisted of two reaction steps, and the target compound was prepared with a yield of 56%. The prepared compound 2 was characterized using ¹H and ¹³C NMR spectroscopy and elemental analysis. During the fluoresce

SUBMITTER: Szechenyi A 

PROVIDER: S-EPMC12364621 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature