Association of the atherogenic index of plasma and high-sensitivity C-reactive protein with incident cardiovascular disease: evidence from a national cohort of middle-aged and older Chinese adults.

ABSTRACT: The atherogenic index of plasma (AIP), an emerging biomarker of lipid dysregulation, and high-sensitivity C-reactive protein (hs-CRP), an established marker of inflammation, are both implicated in the development of cardiovascular disease (CVD). However, their joint impact on CVD risk and the underlying mediation mechanisms remain unclear. This study used data from the China Health and Retirement Longitudinal Study (CHARLS), including 8,763 adults aged ≥45 years with up to 9 years of follow-up. Baseline AIP and hs-CRP levels were measured, and participants were divided into four groups based on the AIP median and hs-CRP threshold (1 mg/L). Multivariable Cox models assessed associations with CVD. Mediation analyses examined direct and indirect effects, including bidirectional mediation. Add

SUBMITTER: Lian PA 

PROVIDER: S-EPMC12364642 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature