Shared molecular profiles of post-laser vision correction ectasia and keratoconus with key differences in <i>CADPS</i>, <i>CPT1B</i>, <i>CIITA</i>, and <i>TBC1D4</i>.

ABSTRACT:

Introduction

Post-laser vision correction (post-LVC) ectasia is a serious complication that is observed in 0.033%-0.66% of corneal refractive surgeries. Similar to keratoconus (KTCN), post-LVC ectasia is classified under the category of "ectatic diseases." We hypothesize that although the mechanistic aspects of post-LVC ectasia and KTCN are distinct, there are notable similarities in the epithelial responses, including shared molecular features.

Methods

A total of 11 post-LVC ectasia, 8 mild myopia (controls), and 28 KTCN patients were included in a retrospective multiomics case-control study. The corneal epithelium (CE) samples obtained from the subjects were separated into different topographic regions (TRs: central, middle, and peripheral), and a tota

SUBMITTER: Jaskiewicz-Rajewicz K 

PROVIDER: S-EPMC12364684 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature