Fufang Duzhong Jiangu granule (FFDZ) ameliorates osteoarthritis development through maintaining subchondral bone homeostasis.

ABSTRACT: Osteoarthritis (OA) is a widespread joint disorder predominantly marked by cartilage degeneration and the hardening of subchondral bone, with a lack of disease-modifying drugs for OA treatment. Fufang Duzhong Jiangu granule (FFDZ), a Chinese medicine, has demonstrated efficacy and safety in the clinical management of OA patients. However, the precise mechanisms through which it operates are still not fully understood. In this study, we set out to explore the protective effects of FFDZ on destabilization of the medial meniscus (DMM) surgery-induced OA mice and elucidate its mechanism underlying the delay of OA progression both in vivo and in vitro. The pathological alterations of OA in DMM-induced mice were examined by gait analysis, μCT, histopathology and immunohistochemistry. We observed

SUBMITTER: Ling H 

PROVIDER: S-EPMC12364815 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature