Phylogenomic analysis of OXA-23-positive and genetic context of rare NDM-1-producing carbapenem-resistant <i>Acinetobacter baumannii</i> isolates in a teaching hospital in China.

ABSTRACT: Nosocomial outbreaks caused by carbapenem-resistant Acinetobacter baumannii (CRAB) strains are rapidly emerging worldwide and are a cause for concern. In this study, a phylogenetic tree of 18 A. baumannii strains collected from a teaching hospital in China was constructed to explore the genetic relationship in the context of genomic insights. The study also aimed to explore the relationship among the strains and to assess the potential spread within the teaching hospital. All CRAB strains were collected from 17 patients, with the majority obtained from sputum samples (55.56%, 10/18). Moreover, 61.11% (11/18) of the CRAB strains were collected from the intensive care unit (ICU). Whole-genome sequencing (WGS) was performed using the Illumina and Oxford Nanopore platforms, and t

SUBMITTER: Dong S 

PROVIDER: S-EPMC12364841 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature