Biofilm formation and role of other pathogenic factors in the virulence of Staphylococcus epidermidis clinical isolates.

ABSTRACT: Medical device-associated infections represent a significant healthcare challenge, as sterilization of the biomaterial often necessitates device removal. The most frequently isolated microorganism in these infections is Staphylococcus epidermidis, a skin commensal capable of causing a wide range of nosocomial infections. The primary virulence factor of S. epidermidis is biofilm formation, which decreases antibiotic efficacy and host immune response. However, additional factors play crucial roles in infection establishment. Understanding the interplay between virulence factors is essential to developing preventive strategies that inhibit microbial adhesion and biofilm development. In this study, we analyzed the presence of genes associated with adhesion and biofilm formation (ica-dependent

SUBMITTER: Fernandez-Calderon MC 

PROVIDER: S-EPMC12364849 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature