A migrasome-related lncRNA signature predicts prognosis and immune response in hepatocellular carcinoma: Implications for biomarker discovery and therapeutic targeting.

ABSTRACT: Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related death, with limited response rates to immunotherapy. Identifying novel biomarkers to predict prognosis and guide treatment is urgently needed. Using TCGA-LIHC data, we identified migrasome-related long non-coding RNAs (MRlncRNAs) associated with HCC prognosis and constructed a two-lncRNA signature (LINC00839 and MIR4435-2HG) through LASSO-Cox regression. The model was validated in an independent cohort (n = 100). Multi-omics analyses were conducted to explore correlations with immune infiltration, immune checkpoints, TMB, MSI, and therapeutic sensitivity. Clinical sample validation and functional assays were performed to verify biological relevance. We knocked down MIR4435-2HG in HCC cells to assess its impact on prol

SUBMITTER: Qin H 

PROVIDER: S-EPMC12364852 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature