A novel Mxene-SPR-based sensor for sensing different types of cancers.

ABSTRACT: Early-stage cancer screening benefits from optical transducers capable of reading minute refractive-index deviations in biofluids. This work models a surface-plasmon-resonance (SPR) biosensor that stacks copper, silicon nitride, and MXene in Kretschmann geometry and evaluates its response to six tumour-related refractive-index increments (Δn = 0.014-0.024 RIU). Transfer-matrix calculations guide a layer-by-layer optimisation: 40 nm Cu, 7 nm Si₃N₄, and two MXene sheets form the best-balanced configuration (Sys₃), while a single MXene layer on 45 nm Cu (Sys₄) offers an alternative with lower optical loss. The optimised MXene sensors raise angular sensitivity to 254° RIU-1 (Sys₃) and 312° RIU-1 (Sys₄) for the breast-T2 model, more than doubling the response of a dielectric-only stack and appr

SUBMITTER: Tene T 

PROVIDER: S-EPMC12364876 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature