Protein functional domain analysis enhances genotype-phenotype associations in comparative genomic studies of <i>Pseudomonas aeruginosa</i>.

ABSTRACT:

Introduction

Pseudomonas aeruginosa (P. aeruginosa) represents a paradigm for studies on antibiotic resistance. Nevertheless, despite the considerable number of genome sequences that have been released in recent years, there is still a paucity of knowledge regarding the genomic determinants of the typical phenotypic traits associated with pulmonary infection.

Methods

The genomes of 40 strains of P. aeruginosa were sequenced over an 8-year period (2007-2014), isolated from the sputum of a single patient with cystic fibrosis in Trentino, Italy. The same isolates were characterised for a panel of 14 phenotypes, including biofilm formation, antibiotic resistance, secretion of siderophores and virulence factors. The phylogenetic coherence of the measured phenotypes

SUBMITTER: Bianconi I 

PROVIDER: S-EPMC12364933 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature