Association of the HDL lipidome with HDL traits before and after exercise training: HERITAGE family study.

ABSTRACT:

Introduction

HDL particle functionality is influenced by its structure, including lipid composition. However, the effects of exercise training on the HDL lipidome and its relationship with HDL-related traits are largely unknown.

Objective

To investigate the HDL lipidome of 154 adults before and after 20 weeks of endurance exercise training in the HERITAGE Family Study.

Methods

The HDL-sized plasma fraction was isolated utilizing FPLC-SEC, followed by untargeted lipidomic analysis using LC/MS. A total of 11 HDL lipid classes were derived from the 341 identified known lipid species. Exercise response of the HDL lipidome and its associations with HDL-related traits were examined, with significance set to FDR < 0.05.

Results

The abundance of 42 HDL lipid species at

SUBMITTER: Dev PK 

PROVIDER: S-EPMC12364975 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature