Validation of Monocular Pupillometry in Healthy Controls and Patients With Autonomic Dysfunction: Pupillary Biomarkers for Autonomic Failure.

ABSTRACT:

Background

Pupillary function is frequently impaired in autonomic disorders, and biomarkers for early diagnosis and disease progression are urgently needed. Pupillometry allows for noninvasive ocular autonomic evaluation. This prospective study technically and clinically validates a handheld monocular pupillometer available for broad application as an autonomic screening tool in autonomic disorders.

Methods

A total of 40 controls and 100 patients with autonomic disorders underwent pupillometry using the PLR-4000(NeurOptics). Pupillary parasympathetic and sympathetic function were assessed by responses to a light stimulus and to 0.5% apraclonidine eye drops, respectively. Test-retest assessments and validations against a binocular device were performed.

Results

In heal

SUBMITTER: Sander L 

PROVIDER: S-EPMC12365000 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature