Metabolic dysfunction impairs Mycobacterium tuberculosis-specific cytokine and chemokine responses in latent tuberculosis and type 2 diabetes mellitus.

ABSTRACT: Type 2 diabetes mellitus (DM) is associated with impaired host immune responses, increasing the risk for latent tuberculosis (TB) infection (LTBI). This study investigated how DM and associated metabolic dysfunction alter Mycobacterium tuberculosis (Mtb)-specific cytokine and chemokine responses. We analysed a cohort of 164 participants with and without DM and/or LTBI. Mtb-specific cytokine/chemokine responses were measured in QuantiFERON-TB Gold-Plus supernatants using a 17-plex Luminex assay to quantify Th1, Th2, Th17, inflammatory and regulatory responses. DM was associated with decreased Mtb-specific IFN-γ, TNF, IL-12, IP-10 and MIP-1α, with increased IFN-α compared to non-DM, suggesting impairment of Th1 and inflammatory pathways. Additionally, pre-DM was not associated with altered c

SUBMITTER: Ssekamatte P 

PROVIDER: S-EPMC12365027 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature