Modular synthesis of CF<sub>2</sub>-containing compounds with PhSO<sub>2</sub>CF<sub>2</sub>H reagent through difluoromethylene radical anion synthon strategy.
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ABSTRACT: Difluoromethylene moiety has gained widespread applications in pharmaceuticals, agrochemicals, and materials owing to its augmented lipophilicity and being bioisosteric to ethereal oxygen. Possessing two orthogonal reactivity modes for bridging an electrophile and a radical acceptor to give gem-difluorides (R1-CF2-R2), the efficient difluoromethylene radical anion synthon (diFRAS) has been long sought after. In this work, we successfully utilize the readily available difluoromethyl phenyl sulfone (PhSO2CF2H) to couple with electrophiles and radical acceptors, thereby enabling PhSO2CF2H to serve as a novel diFRAS in organic synthesis. The generation of radicals (•CF2R) via visible light-promoted homolyti
SUBMITTER: Sun S
PROVIDER: S-EPMC12365036 | biostudies-literature | 2025 Aug
REPOSITORIES: biostudies-literature
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