Mediational effects of reading-related intermediate phenotypes from polygenic scores to reading skills.

ABSTRACT: Reading is a fundamental human capacity that recruits and tunes brain circuitry subserving several neurocognitive skills. Individual differences in reading-related skills are largely influenced by genetic variation. However, the molecular basis of the heritability of reading-related skills remains narrowly replicated. Genome-wide association studies have enabled the computation of cumulative indices (polygenic scores-PGSs) aiming to capture individuals' genetic susceptibility for a given trait. By using a multiple-mediator framework, we investigated whether the associations between a reading-specific PGS (Reading-PGS) and reading decoding and comprehension could be explained by reading-related endophenotypes (i.e., phonological awareness-PA, phonological memory, rapid auditory processing,

SUBMITTER: Remon A 

PROVIDER: S-EPMC12365039 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature