Serotonin and psilocybin activate 5-HT_1B receptors to suppress cortical signaling through the claustrum.

ABSTRACT: Through its widespread reciprocal connections with the cerebral cortex, the claustrum is implicated in sleep and waking cortical network states. Yet, basic knowledge of neuromodulation in this structure is lacking. The claustrum is richly innervated by serotonergic fibers, expresses serotonin receptors, and is suggested to play a role in the ability of psilocybin, which is metabolized to the non-specific serotonin receptor agonist psilocin, to disrupt cortex-wide network states. We therefore addressed the possible role of serotonin, and the classic psychedelic psilocybin, in modulating cortical signaling through the claustrum. We show that serotonin activates 5-HT_1B receptors on anterior cingulate cortex inputs - a primary driver of claustrum activity - to suppress signaling to

SUBMITTER: Madden MB 

PROVIDER: S-EPMC12365098 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature