Plasma interleukin-22 concentration and disease activity in inflammatory bowel disease.

ABSTRACT: The relationship between interleukin-22 and clinical characteristics of patients with inflammatory bowel disease is uncertain. We sought to determine whether plasma interleukin-22 concentrations are associated with disease activity in a large population of patients with inflammatory bowel disease. This was an observational study of patients with Crohn's disease or ulcerative colitis in the Study of a Prospective Adult Research Cohort with IBD (SPARC IBD) from the IBD Plexus registry of the Crohn's & Colitis Foundation in the United States. Interleukin-22 concentrations were measured using an R&D Systems human interleukin-22 enzyme-linked immunosorbent assay. Of 3993 patients included, 1604 with Crohn's disease and 836 with ulcerative colitis had non-missing interleukin-22 baseline samples,

SUBMITTER: Cabrera C 

PROVIDER: S-EPMC12365130 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature