Extract of Bombycis Feces suppressed 3T3-L1 adipogenesis resulting in the regulation of fatty acid-dependent energy consumption.

ABSTRACT: In Oriental medicine, silkworms and their derivatives have been used for anti-inflammatory and diabetic purposes. Bombycis Feces exhibit anti-atopic effects and anti-proliferative activity; however, the role of BF extract (BFE) in adipogenesis and obesity and management remains underexplored. This study examined the effects of BFE on amino acid oxidation during adipocyte differentiation. An adipogenesis model was established using 3T3-L1 cells. Intracellular lipid accumulation was assessed via Oil Red O staining, while cytotoxicity was evaluated using a cell viability assay. The effects of BFE on gene and protein expression, lipolysis, real-time oxygen consumption rate, and substrate oxidation during adipocyte differentiation were analyzed. The involvement of the branched-chain amino acid

SUBMITTER: Lee YK 

PROVIDER: S-EPMC12365174 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature