MOFI-FL, a novel score for detecting hepatic steatosis and predicting cardiometabolic mortality.

ABSTRACT: Hepatic steatosis (HS) is a common condition linked to increased cardiometabolic risk; however, biopsy and imaging-based methods limit the widespread diagnosis, especially in low-resource settings. Here, we develop the MOFI-FL index, a simplified tool for HS detection, validate its performance against vibration-controlled transient elastography (VCTE), and evaluate its association with all-cause and cause-specific mortality. Using data from the Genetics of Atherosclerotic Disease study as our discovery cohort, we developed MOFI-FL, incorporating ALT, glucose, uric acid, and BMI, with computed tomography (CT) as the gold standard of HS. We used the continuous NHANES (2017-2018 cycles, n = 4,405) to validate against VCTE and compare our index with four previously validated HS indices (FLI, H

SUBMITTER: Reyes-Barrera J 

PROVIDER: S-EPMC12365217 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature