Reduced IFN-γ-expressing SARS-CoV-2 specific CD4⁺ T cells and transient CD8 ⁺ T cell activation associate with higher HOMA-IR 1-year post COVID-19 in obese individuals.

ABSTRACT: Insulin resistance is one of the metabolic complications of COVID-19. Our previous study showed a 22% median increase in homeostasis model assessment-estimated insulin resistance (HOMA-IR) in obese individuals at 12 months post-infection compared to acute infection. This study aimed to investigate the association between various subsets of IFN-γ-expressing SARS-CoV-2-specific CD4⁺ and CD8⁺ T cells and insulin resistance in convalescent COVID-19 patients over a one-year post-infection follow-up period. A nested case control study of 47 COVID-19 patients was followed for 12 months post-infection and categorized into three groups based on obesity and changes in HOMA-IR at one year: non-obese without increased HOMA-IR (NO), obese without increased HOMA-IR (O), and obese

SUBMITTER: Kartika R 

PROVIDER: S-EPMC12365270 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature