Sevoflurane inhibition of the developmentally expressed neuronal sodium channel Na_v1.3.

ABSTRACT: Neuronal voltage-gated sodium channels (Na_v) are major targets for the neurophysiological actions of general anesthetics. In the adult brain, cell type-specific effects on synaptic transmission are attributed to the differential sensitivity to volatile anesthetics of specific Na_v subtypes preferentially expressed in mature neurons (Na_v1.1, Na_v1.2, Na_v1.6). Comparatively, developing neurons are more excitable than mature neurons. We determined volatile anesthetic effects on Na⁺ currents mediated by Na_v1.3, the principal Na_v subtype expressed in developing neurons. Sevoflurane at clinical concentrations inhibited peak Na⁺ current of human Na_v1.3 heterologously expressed in HEK293T ce

SUBMITTER: Xiang J 

PROVIDER: S-EPMC12365293 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature