Measuring cerebral hemodynamics and oxygen metabolism indices using NIR-TRS in premature infants from birth to term-equivalent age.

ABSTRACT: Central nervous system development influences the neurological prognosis of premature infants, and their management may be better guided by the evaluation of the oxygen supply-demand balance in brain tissue. Near-infrared time-resolved spectroscopy (NIR-TRS) can measure cerebral oxygen metabolism indices, including cerebral blood volume (CBV), as absolute values. Cerebral hemoglobin oxygen saturation (ScO₂) and the cerebral tissue oxygen extraction rate (cFTOE), but not CBV, have been reported in premature infants. Here, we used NIR-TRS to evaluate the longitudinal changes in these indices, including CBV, in 26 extremely premature infants born at < 30 weeks' gestation without intracranial hemorrhage. ScO₂ was very slightly negatively correlated with postnatal week (r 

SUBMITTER: Nara S 

PROVIDER: S-EPMC12365304 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature