Associations Between Pre-Transplantation T Cell Populations and Acute Cellular Rejection Post-Liver Transplantation-Results From a Prospective Cohort Study.

ABSTRACT: Acute cellular rejection (ACR) remains a common complication post-liver transplantation despite standardised immunosuppressive regimens. Identifying patients at high risk of ACR is challenging, and new tools for prediction are needed. This study aimed to investigate if proportions of circulating T cells as well as different stages of maturation, exhaustion, and activation of T cells pre-transplantation are associated with ACR in liver transplant recipients within the first year post-transplantation. In the prospective ImmuneMO:SOT cohort study, we recruited participants listed for liver transplantation at Copenhagen University Hospital-Rigshospitalet who subsequently underwent liver transplantation. Before transplantation, we collected blood for extensive immune cell profiling using the st

SUBMITTER: Clemmesen JLR 

PROVIDER: S-EPMC12365370 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature