VAMP8 Is an Endosomal v-SNARE That Supports GLP-1 Receptor Recycling in Pancreatic β-Cells.

ABSTRACT:

Article highlights

Vesicle-associated membrane protein 8 (VAMP8) localizes to endosomal vesicles and mediates their exocytosis in pancreatic β-cells. VAMP8-dependent vesicle fusion delivers glucagon-like peptide 1 receptor and GLUT2 to the plasma membrane. VAMP8 overexpression inhibits insulin granule exocytosis. "Newcomer" exocytosis likely involves endosomal compartments, not insulin granules.

SUBMITTER: Liu L 

PROVIDER: S-EPMC12365419 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature