Coronary Microvascular Dysfunction Alters the Pulsatile Behavior of the Resting Coronary Blood Flow.

ABSTRACT:

Background

Variations in resting pulsatile coronary flow velocity acceleration/deceleration characteristics (dU/dt) with respect to epicardial lesions and coronary microvascular dysfunction (CMD) remain incompletely understood.

Method

The coronary dU/dt pattern was extracted from the first derivative of the intracoronary Doppler velocity signal. Univariable and multivariable models evaluated the relationships between the dU/dt amplitudes, epicardial disease as well as CMD, defined by a blunted coronary flow reserve (CFR) adjusted for the concomitant epicardial disease severity (fractional flow reserve, FFR) yielding the microvascular resistance reserve (MRR). Functional CMD was defined by a blunted MRR (≤ 3.0) but normal hyperemic microvascular resistance (hMR < 2.5) whereas

SUBMITTER: Tas A 

PROVIDER: S-EPMC12365450 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature