Associations of hepatic steatosis index in early pregnancy with perinatal outcomes: A prospective birth cohort study.

ABSTRACT:

Background

This study aims to evaluate the association between maternal hepatic steatosis index (HSI) in the first trimester and adverse perinatal outcomes.

Methods

A prospective birth cohort study was conducted from 19 February 2018 to 31 December 2022 in China. Logistic regression models and restricted cubic splines were used to estimate the associations of maternal HSI in early pregnancy and the risk of perinatal outcomes. Subgroup analyses stratified by maternal age and gravidity were carried out.

Results

A total of 42,589 participants were included in this study. The overall prevalence of caesarean delivery, preterm birth, large-for-gestational age (LGA), shoulder dystocia and low Apgar scores were 39.17%, 5.18%, 9.45%, 0.92% and 0.77%, respectively. With the inc

SUBMITTER: Su S 

PROVIDER: S-EPMC12365500 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature