Total ginsenosides and ginsenoside Rb2 delay hepatocyte senescence by regulating NAD⁺ metabolism and promoting IDO2/QPRT expression.

ABSTRACT: Imbalances in nicotinamide adenine dinucleotide (NAD+) homeostasis accelerate aging, and targeting NAD+ metabolism is a potential strategy for delaying aging. Ginsenoside, as the main active ingredient of Panax ginseng Meyer, exert age-delaying effects. However, the potential molecular mechanism by which total ginsenosides (GS) affect NAD+ metabolism remains unclear. The ability of GS to improve the health status of aging mice was evaluated by water maze, new object recognition, cardiac ultrasound, biochemical analysis, and H&E staining. LC-MS was used to detect NAD+ metabolites. Senescence-associated secretory phenotypes (SASPs), NAD+ level and mitochondrial function were used to assess cellular senescence status. Screening of active components of GS in mouse hepatocytes (AML12) based on

SUBMITTER: Guo C 

PROVIDER: S-EPMC12365506 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature