White matter hyperintensity burden and infarct volume predict functional outcomes in anterior choroidal artery stroke: a multimodal MRI study.

ABSTRACT: To investigate the relationship between white matter hyperintensity (WMH) burden and infarct volume with functional outcomes in patients with anterior choroidal artery (AChA) territory infarction. This retrospective cohort study included patients with AChA territory infarction admitted to two comprehensive stroke centers between September 2018 and September 2024. WMH burden was assessed using the Fazekas visual rating scale and an automated volumetric quantification method based on lesion prediction algorithms. Acute infarct volume was precisely measured using fully automated threshold segmentation. Poor functional outcome was defined as a modified Rankin Scale (mRS) score ≥3 at 90 days. Associations were evaluated using multivariable logistic regression models with stepwise adjustment for

SUBMITTER: Gao W 

PROVIDER: S-EPMC12365522 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature