Red ginseng extract enhances mitochondrial function and alleviates immunosenescence in T cells.

ABSTRACT:

Background

Mitochondrial function is essential for immune cell regulation, and its decline is linked to aging and chronic diseases. Impaired activity contributes to inflammation and reduced immunity. This study explores Red ginseng extract (RGE)'s potential in enhancing mitochondrial function and immune cell viability, offering benefits in mitigating immunosenescence.

Methods

T cells and macrophages from young (12-week-old) and aged (20-month-old) mice were treated with RGE to assess mitochondrial function and cell viability. Flow cytometry evaluated immune cell populations and cytokine expression in splenocytes, while single cell transcriptomics analyzed RGE-induced transcriptional changes in T cells and macrophages.

Results

RGE treatment improved mitochondrial oxyge

SUBMITTER: Lee HY 

PROVIDER: S-EPMC12365556 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature