Converting Evidence-Based Summary of Findings Evidence Tables Into Decision Analytical, Quality Adjusted Life Years (QALY) and Life Expectancies Metrics: A Tutorial.

ABSTRACT:

Rationale, aims, and objectives

We have recently succeeded in integrating evidence estimation with decision-analytical frameworks, thereby addressing a major challenge in advancing the science of evidence-based medicine (EBM) and clinical practice guidelines. However, the primary output of our analysis was expressed as net differences in expected utility (ΔEU) between competing treatment interventions. Although expected utility is a standard decision-analytic metric, it is not intuitively understood by most clinicians. Here, we demonstrate how ΔEU can be converted into gains in quality-adjusted life years (QALYs) and life expectancy (LE).

Methods

We begin with GRADE (Grading of Recommendations Assessment, Development, and Evaluation) Summary of Findings (SoF) tables-the prim

SUBMITTER: Hozo I 

PROVIDER: S-EPMC12365584 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature