Chronic intermittent alcohol yields sex-specific disruptions in cortical-striatal-limbic oscillations in rats.

ABSTRACT:

Background

There are significant sex differences in the causes and consequences of alcohol misuse, suggesting that sex-specific neurobiological mechanisms might drive drinking. The current study used a rodent model to determine whether chronic intermittent alcohol exposure impacts cortical, striatal, and limbic neural circuits in a sex-specific manner.

Methods

Female and male Sprague-Dawley rats were trained to self-administer 10% alcohol before implanting bilateral electrodes into the infralimbic cortex (IL), nucleus accumbens shell (NAcSh), and central nucleus of the amygdala (CeA). Half of the rats were then exposed to 4 weeks of chronic intermittent alcohol (CIA) vapor. During acute withdrawal, local field potentials (LFPs) were recorded in the IL, NAcSh, and CeA. Using

SUBMITTER: Hewitt KA 

PROVIDER: S-EPMC12365586 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature