Development of Substrate-Independent Antifouling and Bactericidal Surfaces Using Visible Light Cross-Linked Hydrogel Coatings for Biomedical Applications.

ABSTRACT: Preventing biofouling and bacterial infections are pivotal issues in developing implantable biomaterials. Zwitterionic hydrogels stand out for their antifouling effects and high biocompatibility, making them ideal for biomedical applications. However, the lack of direct bactericidal activity and the limited applicability to various materials are key challenges to be addressed in these hydrogel coatings. To address this, a dual-functional hydrogel coating with synergetic antifouling and biocidal properties is proposed to prevent the initial infection and consequent biofilm formation, which can be applied to various types of substrates. This coating is fabricated via photo-crosslinking, combining representative zwitterionic polymer, poly (sulfobetaine methacrylate) (pSBMA), with a cationic b

SUBMITTER: Roh S 

PROVIDER: S-EPMC12365621 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature