Biphasic Granular Bioinks for Biofabrication of High Cell Density Constructs for Dermal Regeneration.

ABSTRACT: Chronic wounds and severe skin injuries pose significant clinical challenges, as existing treatments like cultured epidermal autografts and tissue engineering strategies fail to regenerate functional dermal tissue effectively. These methods often result in scarring due to poor tissue integration, low cell density, and limited extracellular matrix (ECM) production. Conventional skin tissue engineering relies on time-intensive cell expansion, producing constructs that lack the complexity of native dermal structures. Here, a bioprintable biphasic granular hydrogel bioink (µInk) based on cell-laden porous gelatin microcarriers (PGMs) is presented, enabling fabrication of ultra-high cell density constructs that promote ECM production for dermal regeneration in vitro and in vivo. Primary human d

SUBMITTER: Shamasha R 

PROVIDER: S-EPMC12365623 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature