Peptide Display Directed Assembly of Biopolymer Core-Silica Shell Particles.

ABSTRACT: The unique hierarchical core-shell structures of silica capsules contributing to delivery of active compounds have attracted broad interest. To overcome the limited cargo-loading capacity of silica capsules but harness the silica mediated cargo protection, Escherichia coli is engineered to efficiently assemble submicrometer-sized biopolyester particles (BPs) that densely display the positively charged RK1 peptide ((RKK)₄G₃Y), which mediates nucleation and growth of silica. The peptide-coated BPs are tested as biomimetic template and treatment with silica precursors results in formation of BP core-silica shell structures. Electron microscopy reveals changes in BP surface morphology consistent with silica shell formation further confirmed through Fourier transform infra

SUBMITTER: Pande DC 

PROVIDER: S-EPMC12365626 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature