Risk Factors for Severe Pediatric Invasive Group A Streptococcal Disease.

ABSTRACT:

Importance

An increase in pediatric cases of invasive group A streptococcus (iGAS) disease was noted in the Netherlands starting in early 2022. GAS disease can range from mild to life-threatening invasive infections. Clinical and public health decisions rely on timely and detailed reporting of clinical data.

Objective

To determine risk factors associated with severe pediatric iGAS, defined as requiring admission to an intensive care unit and/or death, and to analyze pediatric iGAS incidence, presentations, and outcome between pre-COVID-19 pandemic (January 2015 to March 2020), COVID-19 pandemic (April 2020 to December 2021), and post-COVID-19 pandemic (January 2022 to June 2024) periods.

Design, setting, and participants

This observational, retrospective and prospecti

SUBMITTER: van Kempen EB 

PROVIDER: S-EPMC12365701 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature