Epstein-Barr Virus Seropositivity, Immune Dysregulation, and Mortality in Pediatric Sepsis.

ABSTRACT:

Importance

Epstein-Barr virus (EBV) seropositivity is associated with chronic immune dysregulation conditions, including multiple sclerosis, systemic lupus erythematosus, post-COVID-19 condition, and multiple cancers. Sepsis is an acute immune dysregulation condition attributed to 1 of 5 global deaths.

Objective

To assess causal associations among EBV seropositivity, immune dysregulation, and mortality in children with sepsis.

Design, setting, and participants

This cohort study analyzed 320 children with sepsis in the 9-center Eunice Kennedy Shriver National Institutes of Child Health and Development Collaborative Pediatric Critical Care Research Network Phenotyping Pediatric Sepsis-Induced Multiple Organ Failure (PHENOMS) study who had not previously received intrave

SUBMITTER: Sriram A 

PROVIDER: S-EPMC12365707 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature